Cell Therapy Limits Myofibroblast Differentiation and Structural Cardiac Remodeling
نویسندگان
چکیده
منابع مشابه
Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.
BACKGROUND Experimental cell therapy attenuates maladaptive cardiac remodeling and improves heart function. Paracrine mechanisms have been proposed. The effect of cell therapy on post infarction cardiac fibroblast and extracellular matrix (ECM) regulation was examined. METHODS AND RESULTS Vascular smooth muscle cells (VSMC) were injected into the border zone of subacute infarcted syngeneic Fi...
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Irreversible airflow limitation in asthma is associated with airway remodeling in which the differentiation of fibroblasts to myofibroblasts plays a pivotal role. In asthmatic airways, excessive production of reactive nitrogen species (RNS) has been observed. The aim of this study is to evaluate whether peroxynitrite, one of the RNS, can affect the differentiation of fibroblasts to myofibroblas...
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2012
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.111.965889